NADH (Nicotinamide Adenine Dinucleotide + Hydrogen) is a naturally occurring high-energy coenzyme in the human body and a core carrier of cellular energy metabolism. As the direct driver of ATP, the biological energy currency, NADH participates in the mitochondrial electron transport chain, helping convert nutrients from food into usable energy (ATP).
Key Features:
Naturally Present: Synthesized daily by the body, but levels decline significantly with age (reduced by ~50% after age 30).
Dual-State Conversion: Cycles between oxidized (NAD⁺) and reduced (NADH) forms to maintain cellular redox balance.
Derived from Vitamin B3: Produced from niacin (Vitamin B3) and belongs to the NAD⁺ precursor family, alongside NMN/NR.
Function: Directly engages in the citric acid cycle and electron transport chain to enhance ATP synthesis efficiency.
Mechanism: Activates longevity protein Sirtuins (NAD⁺-dependent) and enhances telomerase activity to delay cellular aging.
Effect: Crosses the blood-brain barrier to support neuron function, improving memory and focus.
Pathway: Regenerates glutathione (GSH), neutralizes free radicals, and reduces collagen degradation.
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