Chemical Nature: NR (Nicotinamide Riboside) is a derivative of vitamin B3 (niacin) and a precursor to NAD+ (nicotinamide adenine dinucleotide), a critical coenzyme for cellular energy metabolism and repair.
Sources: Found in trace amounts in foods like milk and yeast, but primarily consumed as a dietary supplement.
Key Mechanism: NR indirectly exerts antioxidant effects by boosting NAD+ levels:
NAD+ supports mitochondrial energy (ATP) production, enhancing cellular metabolism.
Activates longevity proteins (e.g., Sirtuins) to aid DNA repair and reduce oxidative stress.
NAD+ levels decline with age; NR supplementation may mitigate age-related decline.
Niacin (NA): May cause skin flushing.
Nicotinamide (NAM): High doses might inhibit Sirtuins.
NMN (β-Nicotinamide Mononucleotide): Similar to NR, but NR is more readily absorbed.
Anti-aging supplement (energy, cognitive support).
Metabolic health (blood sugar, cholesterol).
Exercise recovery (reducing muscle oxidative stress).
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